Expression of sclerostin and bone morphogenetic protein-7 (BMP-7) in serum of patients with chronic kidney disease-mineral and bone disorder (CKD-MBD) and their correlation with calcium and phosphorus metabolism

Calcium and phosphorus metabolism involves in patients with chronic kidney disease-mineral bone disorder (CKD-MBD). Sclerostin morphogenetic protein-7 (BMP-7) are closely related to formation. This study aims assess sclerostin BMP-7’s role renal function, blood calcium CKD-MBD. 86 CKD-MBD were collected as the case group healthy subjects selected control group. ELISA was used detect BMP-7 serum level. The automatic biochemical analyzer liver function. Blood level, iPHT level detected by immunoradiation. No differences found regarding age, gender, BMI between (P > 0.05). Compared controls, had significantly reduced eGFR increased Scr, BUN, iPTH < 0.05) (t = 33.86, P 0.001), 329.38, 0.001). levels correlated positively negatively eGFR, levels, independent risk factors for changes may be important affecting occurrence of Renal